From Non-Alcoholic Fatty Liver Disease to Liver Cancer: Microbiota and Inflammation as Key Players

It is estimated that 25% of the world’s population has non-alcoholic fatty liver disease. This disease can advance to a more severe form, steatohepatitis (NASH), with greater probability progression cirrhosis and hepatocellular carcinoma (HCC). NASH could be characterized as necro-inflammatory complication chronic hepatic steatosis. The combination factors lead its HCC in setting inflammation not clearly understood. portal vein main route communication between intestine liver. allows transfer products derived from response pathway bile antibody secretion intestine. intestinal microbiota performs fundamental role regulation immune function, but it undergo changes alter functionality. These also contribute cancer by disrupting system causing dysfunction, both which are implicated development. In this article, we address link inflammation, HCC. We review different vitro models, well recent clinical trials addressing microbiota.